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Demecarium bromide, 95% (HPLC)
CAS No 67745
제품번호 AK Sci.(USA)
제조사 수입산
재고 1 EA
금액 177,000원
포장단위




※ 화학명 : Demecarium bromide, 95% (HPLC)

 

※ 등급 : APIs and Bioactives > AChR Agonists

 

※ 판매 포장단위 : 25mg , 100mg

 

※ 화학식 : C32H52Br2N4O4

 

※ CAS # : [56-94-0]


 

IDENTITY
CAS Registry #: [56-94-0]
MDL Number: MFCD00152376
MF: C32H52Br2N4O4
MW: 716.59
EINECS: 200-301-9
SPECIFICATIONS & PROPERTIES
Purity: 95% (HPLC)
Available Spectra:

 

LCMS, HPLC

Physical Form: White powder
Melting Point: 162-167°C
Long-Term Storage:

 

Store at room temperature

Shipping: Not Regulated for Shipping

BIOLOGICAL INFO
Application(s): Acetylcholinesterase inhibitor

REVIEW
Demecarium is an indirect-acting parasympathomimetic agent, also known as a cholinesterase inhibitor and anticholinesterase. Cholinesterase inhibitors prolong the effect of acetylcholine, which is released at the neuroeffector junction of parasympathetic postganglion nerves, by inactivating the cholinesterases that break it down. Demecarium inactivates both pseudocholinesterase and acetylcholinesterase. In the eye, this causes constriction of the iris sphincter muscle (causing miosis) and the ciliary muscle (affecting the accommodation reflex and causing a spasm of the focus to near vision). The outflow of the aqueous humor is facilitated, which leads to a reduction in intraocular pressure. Of the two actions, the effect on the accommodation reflex is the more transient and generally disappears before termination of the miosis.
REFERENCES
[1] Ward DA, Abney K, Oliver JW: The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs. Vet Ophthalmol. 2003 Mar;6(1):23-5.
[2] Krohne SG: Effect of topically applied 2% pilocarpine and 0.25% demecarium bromide on blood-aqueous barrier permeability in dogs. Am J Vet Res. 1994 Dec;55(12):1729-33.
[3] Gum GG, Gelatt KN, Gelatt JK, Jones R: Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma. Am J Vet Res. 1993 Feb;54(2):287-93.

Risk Description(s)
R36/37/38: Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25: Avoid contact with skin and eyes.